The therapeutic effect results from the complementary effects of the unique combination of biologically active compounds found in the green-lipped mussel as follows:
GLM Extract contains Glucosamine, Chondroitin sulphate, Hyaluronic acid and Dermantan Sulphate. GLM Extract is a natural source of glucosamine - not free glucosamine - a component of joint cartilage and of synovial fluid that has been shown to slow the structural damage within arthritic joints. Chondroitin sulphate makes up the basic ground substance of both, the bone and cartilage and may inhibit catabolic cytokine initiated degradation of the cartilage. Hyaluronic acid is a nonsulphated GAG found in the proteoglycans structure and it also contributes to the viscosity of the synovial fluid.
Cytokines are chemical messengers produced by cells in response to a variety of stimuli. Catabolic cytokines present in arthritic joints perform a number of detrimental functions, which result in an accelerated breakdown of cartilage and enhanced inflammation. The catabolic cytokines, Interleukin-1 (IL-1), Interleukin-2 (IL-2) and Tumor Necrosis Factor - alpha (TNF-) are the ones mainly associated with destructive function in the arthritic joint due to their influence on neutrophils infiltration, matrix metalloproteinase and proinflammatory prostaglandin production. Studies using arthritic rats have demonstrated the inhibitory effect of GLM Extract on neutrophils activity and pro-inflammatory prostaglandin synthesis along with the inhibition of catabolic cytokine activity at the cellular level.
GLM Extract is a selective inhibitor of cyclo-oxygenase type 2. Inhibiting the activity of cycloxygenase enzymes, which convert cell membrane phospholipids into pro-inflammatory prostaglandins, is an important anti-inflammatory mechanism. However, there are two isozyme of cycloxygenase, designated as COX-1 and COX-2. The COX-1 isozyme is a constitutional enzyme that has an important role in maintaining the health and integrity of the digestive system, kidney function and platelet aggregation whereas, COX-2 isozyme is induced in response to an inflammatory stimulus. The fact that GLM Extract is able to inhibit COX-2 selectivity without inhibiting COX-1 activity means that the product does not have any damaging effects on the stomach and does not adversely affect kidney function or platelet aggregation.
In addition to cyclo-oxygenase inhibitory activity, GLM Extract has been shown to inhibit 5-Lipoxygenase activity in stimulated human polymorphonuclear leukocytes in vitro. 5-Lipoxygenase activity is similar to cycloxygenase enzymic activity involving the conversion of endogenous arachidonic acid to proinflammatory and broncho-constrictive leukotrienes. These leukotrienes are adversely indicated in arthritic and asthmatic disorders and inhibition of their function is important for the control of these disorders.
Apoptosis is a term used to describe programmed cell death. This is a normal physiological function but can become uncontrolled in some disease states. In arthritis, an elevated level of apoptosis can occur in the body′s white blood cells (T-lymphocytes). T-lymphocytes have been shown to be important mediators in the tissue destruction seen in rheumatoid arthritis. Animal studies have shown that GLM Extract inhibits the accumulation of T-lymphocytes at inflammatory sites. However, this is still to be proven in the case of human lymphocytes.
Histamine production is normally associated with allergy reactions. However, it is also a component of the acute phase of inflammation and its control is therefore influential in the symptomatic relief of inflammatory disorders such as arthritis. Japanese researchers discovered that GLM Extract naturally contains an active anti-histamine component in the form of Phospholipid Lysolecithin. Although anti-histamine preparations are not a standard part of treatment of arthritic diseases, their complementary function in inhibiting the acute-mediator driven phase of inflammation is beneficial.
GLM Extract is prepared from marine mussels, which have naturally assimilated micronutrients from their sea environment, in a manner, which retains all the components in a stable and functional state. Some minerals such as boron, manganese and copper have influence as anti-inflammatory agents either directly or synergistically with other mediators. Fat-soluble vitamins such as A, D, E and K are not in excess in GLM Extract and there is no danger of hypervitaminosis or biosynthesis of excess calcium.
Mrs. Chitra Narain
Retired Media Professional, Jangpura, New Delhi
In the 1980s I started suffering from arthritis. I went to doctor he advised me knee replacement. I was not ready for it. One day I saw an advertisement in the newspaper regarding Seatone. I started taking two capsules every day. Use of Seatone provided me miraculous results.
Mrs. Renuka Gupta
Retired MNC Professional, Lajpat Nagar, New Delhi
I am suffering from arthritis from 30 years. I used to suffer severe knee pain. I consulted many doctors but I was not able to get treated. One day I came to know about Seatone from a friend. I started using it in 2003. I felt a great relief and comfort with its continuous use.
Mrs. Abha Saxena
Two years back I felt pain in my foot. I went to the doctor, he diagnosed degeneration of knee bone through X-ray. He advised me knee replacement and some medicines. I was not much benefited with the medicines. One day I came to know about Seatone at my friend′s place. I used Seatone regularly for two months. After one year again I suffered from the same pain. I again started Seatone capsules and now I am completely fine.
Mr. Rajeev Sharma
Sr. Auditor, Government Service, Palwal, Haryana
My mother was suffering from arthritis 5-6 years back. She was even unable to walk. But she was not ready to visit doctors. Therefore I started researching about the treatments of arthritis. I came to know about Seatone. My mother used Seatone for 8-9 months. Now she is quite fine.
Col. Retd. Anthony Abraham
Indian Army, Vasant Kunj, New Delhi, Indian Army, Vasant Kunj, New Delhi
Mrs. Nivedita Kamal
Retired Banker, Dwarka, New Delhi, Retired Banker, Dwarka, New Delhi
Dr. Krishan Bir Chaudhary
President of Bharatiya Krishak Samaj, President of Bharatiya Krishak Samaj
Mr. Ajay Gupta
Businessman, Faridabad, Haryana, Businessman, Faridabad, Haryana
Healtheries Seatone, a 100% extract of the New Zealand Green Lipped Mussel (GLM), contains anti-inflammatory agents, immune modulators and many essential building blocks, all naturally occurring substantial therapeutic agents known to maintain joint mobility & well being.
Seatone Vs Other GLME Brands
For the formation of GLME extracts the processing conditions vary. The production of Seatone meets the internationally accredited standards. Its preservation starts right after its harvesting. Its quality of raw material, processing methods and product quality is tested by the testing agencies.
What is Squalene?
Squalene is an unsaturated isoprenoid that occurs naturally in several seeds and also found in the bodies of animals. Among vegetable oils, olive oil is the rich source of squalene. It is also found in human body.
How long Seatone should be taken to see the desired results?
On the onset of arthritis, GLME use provides immediate relief. In grade-2 of arthritis it will take much more time and in grade-3 of arthritis, you need to be patient because regeneration is a slow process. The reduction of inflammation and synthesis of the membrane will be delayed in this grade- 3.
What are the Risk Factors for Arthritis?
There are several factors that increase the risk of arthritis. The main factor is the gender of a person. Women are more prone to develop arthritis than men. The other factors are your lifestyle, age and genetics that contribute to increased the risk of arthritis.
Arthiritis in Female
The number of women suffering from arthritis is more than the number of men suffering from arthritis. There are a number of factors that contribute to the development of arthritis in women, such as the number of births given by a woman. Arthritis can affect any section of society.
What is Osteoarthritis & its symptoms, diagnosis, prevention and treatment alternative available?
Seatone Vs Other GLME Brands
For the formation of GLME extracts, the processing conditions vary. The production of Seatone meets the internationally accredited standards. Its preservation starts right after its harvesting. Its quality of raw material, processing methods and product quality is tested by the testing agencies.
Obesity and Arthritis
Obese people are more susceptible to develop arthritis then the healthy people because their legs are not able to support the excessive weight of their upper body. Obese people are more likely to develop knee problems. The only way for the obese people to manage arthritis is to reduce their weight in a scientific way.
What are the risk factors affecting Women and Osteoarthritis?
There are a number of factors responsible for the higher risk of developing osteoarthritis in women. The major one is diet. During pregnancy, the calcium is extracted by the fetus and after the birth of baby milk production extracts a lot of calcium, which makes the bones of women weak. Therefore, the chance of developing arthritis increases.
Is GLME Safe For Diabetic Patients Suffering From Arthritis?
GLME is safe for diabetic patients suffering from arthritis as it has a marine origin. The marine foods are recommended for the patients with diabetes. There is no harm linked with GLME for the diabetic patients.
Green Lipped Mussel in Rheumatoid Arthritis Pain Management
GLME of New Zealand waters is an excellent remedy for controlling rheumatoid arthritis. GLME contains various components that act as a building block for the collagen. They rebuilt the damaged tissues and with their continuous use, cartilage can come back to their normal conditions.